Browsing by Author "Mahdi,M. A"

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Evaluation of Serum Uric Acid and C- Reactive Proteins in Sudanese with Hypertension in Khartoum State
(INTERNATIONAL JOURNAL OF ADVANCE SCIENTIFIC RESEARCH AND ENGINEERING TRENDS, 2017) Abd Elkareem,Yassir Amir M; Mohamed,Rihab Akasha; Mahdi,M. A
Abstract—Uric acid is commonly associated with hypertension; recent experimental and clinical studies suggest that uric acid could have a contributory role in the pathogenesis of elevated blood pressure. Individuals at risk for developing hypertension and cardiovascular disease, frequently have evidence for a systemic inflammatory response, often marked by elevations of C- reactive protein (CRP) in their blood. Elevated levels of CRP have emerged as one of the most important predictors of myocardial infarction, stroke, and vascular death, with prognostic value exceeding that of LDL cholesterol. Aim: To evaluate, serum uric acid and CRP levels in Sudanese hypertensive patients in Khartoum state. Material and methods: 100 subjects in the age group of 25- 60 years, divided into two groups of hypertensive and control healthy normotensive group. (54) Patients suffering from hypertension and (46) ages matched non hypertension subjects, who were volunteered to be included in the study. Blood samples were collected in plain container for estimation of Serum C-RP and uric acid levels, Serum CRP levels were detected (qualitatively) using latex agglutination method (Spinreact Kit; 2016). Uric acid was estimated by quantitative commercial kit method (on Autoanalyzer Mindray. BS200). Venous blood sample was drawn from all subjects, allowed to clot at room temperature for 1–3 hours and serum was separated by centrifugation for 15 min at 3000 r. p. m. Data were analyzed using statistical package for the social sciences (SPSS). Result: The patients of hypertension under study comprised of 51.9% males and 48.1% females while the control comprised of 52.2% males and 47.8% females, the age range between 25 years to 60 years. Uric acid levels were high in 66.7 % of patients and normal in 33.3 % of patients. However uric acid levels observed within normal range in all normotensive subjects (control). CRP in 63 % of patients was positive while 37 % were negative and all control was negative. There was strong significant positive correlation between uric acid and CRP with P- value 0.000. Conclusion: Serum uric acid levels were found higher in hypertensive patients than in healthy individuals. Serum CRP in hypertensive patients shows higher percentage than in healthy individuals.
MEASUREMENT OF PLASMA TOTAL PROTEIN, ALBUMIN AND UREA IN HEALTHY SUDANESE PREGNANT WOMEN
(World Journal of Pharmaceutical Research, 2018) Mahdi,M. A; Elgzoly,Elhady Ahmed Elhady; Ibrahim,Alaldin A; Osman,Hassan. S; Mohamed,Rihab Akasha
Background: Pregnancy is characterized by extensive maternal physiological adjustments involving a variety of metabolic processes. These characteristic changes are often reflecting in the results of laboratory tests, such that value in healthy pregnant women may fall outside the normal ranges of non-pregnant women. This study aimed to assess the concentration of serum total protein, albumin and blood urea among Sudanese pregnant women during the three trimesters and to compare them with non-pregnant women’s. Methods: Case control study conducted during the period from January to March 2014 to compare serum levels of total protein, albumin and urea of 80 pregnant women (18 at 1st trimester, 23 at 2nd trimester and 39 at 3rd trimester) with 20 healthy non pregnant women. Results: Means of serum levels of total protein in the 1st trimester showed no significance comparing to control group, while serum albumin and urea levels significantly decreased. In second and the third trimesters all total protein, albumin and urea were significantly decreased compared to control group. Conclusion: Total protein, serum albumin and blood urea were altered during the pregnancy period compared to non-pregnant women but not to the levels of abnormality.