Research Papers
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Item Association of Platelet Serotonin Levels in Alzheimer’s Disease with Clinical and Cerebrospinal Fluid Markers(Journal of Alzheimer’s Disease, 2016) Tajeddinna,Walid; Fereshtehnejad,Seyed-Mohammad; Ahmed,Mohammed Seed; Yoshitaked,Takashi; Kehr,Jan; Shahnaz,Tasmin; Milovanovic,Micha; Behbahani,Homira; Hoglund ,Kina; Winblad,Bengt; Cedazo-Minguez,Angel; Jelic,Vesna; Jaremo,Petter; Aarsland,DagIntroduction: Serotonin (5-HT) is involved in the pathology of Alzheimer’s disease (AD). Objective: We aimed to measure 5-HT level in platelets in AD and explore its association with cerebrospinal fluid (CSF), AD biomarkers (amyloid- 1-42 (A42), total tau (t-tau), and phosphorylated tau (p-tau)), and clinical symptoms. Methods: 15 patients with AD and 20 patients with subjective cognitive impairment (SCI) were included. 5-HT metabolites were measured, in a specific fraction, using high performance liquid chromatography with electrochemical detection (HPLC- ECD). Results: Significantly lower 5-HT concentrations were observed in AD patients compared to SCI patients both after normal- ization against total protein (p = 0.008) or platelet count (p = 0.019). SCI patients with lower 5-HT level have higher AD CSF biomarkers, total tau (p = 0.026) and tau/A42 ratio (p = 0.001), compared to those with high 5-HT levels. Conclusion: AD patients have reduced platelet 5-HT levels. In SCI, lower 5-HT content was associated with a higher AD-CSF biomarker burden.