Faculty of Medical Laboratory Sciences
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Item IMPACT OF ANALYTICAL ERROR IN AN ESTIMATION OF LIVER ENZYMES(European Journal of Biomedical and Pharmaceutical Sciences, 2018) Suliman,Rowa; Modawe,Gad Allah; Akasha,Rihab; Mahdi,Mohammed ABackgrounds: Laboratory professionals should produce accurate, sensitive and specific information using new age technologies to guide clinical decision making. It is the role of laboratory professionals to inform physicians about which tests have the highest effectiveness in given clinical conditions. Objective: The objective of this study was to determine the analytical errors of liver enzymes, and also the AST, ALT and ALP levels are a valuable aid primarily in the diagnosis of liver disease. Methodology: cross sectioned study was conducted during the period of the November to April 2013, to measure the accuracy and precision of laboratories by estimation of AST, ALT and ALP in normal and pathological control sera in 10 clinical laboratories in Khartoum state, Sudan. The percentage were used to assess the laboratories quality management requirement of each selected laboratories. Results: The study showed that10% of total laboratories give excellent level for normal and pathological control materials of AST, ALT and ALP while 60% of total laboratory gives poor level for normal and 50% for pathological for AST, 70% of total laboratory gives poor level for normal and 60% for pathological for ALT and 90% of total laboratory gives poor level for normal and70%for pathological for ALP. Conclusions: In spite of all these laboratory have Implementation of quality control procedures, Documentation and interpretation of control material results, and the instrument used to estimate liver enzymes is automated machine and calibration was done daily by senior staff, there is a variation between AST, ALT and ALP analytical results among the normal and pathological level due to technical problems such as inappropriate sample handling, failure to calibrate pipettes. Based on this result we conclude that the absence of total quality management especially the adopted quality requirement for clinical chemistry laboratories lead to gap of implementation and weak laboratory performance.Item ASSESSMENT OF FREE PROSTATIC SPECIFIC ANTIGEN/TOTAL PROSTATIC SPECIFIC ANTIGEN RATIO, LIPOPROTEINS, ESTRADIOL AND C – REACTIVE PROTEIN IN PROSTATIC TUMORS(WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2018) Mahdi,Mohammed A; Akasha,Rihab; Modawe,Gad Allah; Sharfy,Abd Alrauf; Khattab,Abd ElHafiz HBackground: Prostate tumors, especially prostate cancer have severe complications such as spreading to neighboring organs. Objectives: This study was performed to compare between levels of free prostatic specific antigen (fPSA)/ total prostatic specific antigen (tPSA) ratio, lipoproteins, estradiol and C-reactive protein with prostatic cancer and benign prostatic hyperplasia patients. Materials & Methods: This study was designed as prospective case control and it was done in Soba University hospital and Khartoum Teaching hospital in Khartoum state. It was performed on 200 men (50–65 years old); 100 healthy individuals as controls and 100 patients; 50 patients with prostate cancer and 50 with benign prostate hyperplasia who were diagnosed by biopsy and histopathology. Results: There was significant increase in the mean value of total PSA in PCa patients and BPH more than controls with (P-value 0.003). Free PSA also showed significant increase in PCa patients and BPH more than controls with (P-value 0.040). The ratio of free to total PSA was decreased in PCa patients (7 %), but increased in BPH (34 %) and in control (67 %) with P-value (0.000). The mean value of serum cholesterol, triglyceride, n LDL and HDL were significantly low in PCa than BPH and control with (P-value 0.035, 0.000, 0.015 and 0.002) respectively. The mean of serum Estradiol level and CRP was increase in PCa than BPH and control with (P- value 0.025 and 0.000) respectively. Conclusion: Serum fPSA/tPSA ratio was less than 25% in patients with PCa. Total cholesterol, HDL and LDL were low in concentration in PCa patients than in those with BPH patients and control. Serum Estradiol levels increases in PCa patients more than in BPH patients and control. Serum CRP concentration was higher in PCa patients than in those with BPH and control.