National University Biomedical Research Institute (NUBRI)
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Item Bioinformatics in Sudan: Status and challenges case study: The National University-Sudan(PLOS COMPUTATIONAL BIOLOGY, 2021) Mohamed, Sofia B; Kambal, Sumaya; Ibrahim, Sabah A.E.; Abdalwhab, Esra; Munir, Abdalla; Ibrahim, Arwa; Ali, Qurashi MohamedThe ever increasing applications of bioinformatics in providing effective interpretation of large and complex biological data require expertise in the use of sophisticated computa tional tools and advanced statistical tests, skills that are mostly lacking in the Sudanese research community. This can be attributed to paucity in the development and promotion of bioinformatics, lack of senior bioinformaticians, and the general status quo of inadequate research funding in Sudan. In this paper, we describe the challenges that have encountered the development of bioinformatics as a discipline in Sudan. Additionally, we highlight on spe cific actions that may help develop and promote its education and training. The paper takes the National University Biomedical Research Institute (NUBRI) as an example of an institute that has tackled many of these challenges and strives to drive powerful efforts in the devel opment of bioinformatics in the country.Item Proteomics and Docking Study Targeting Penicillin Binding Protein and Penicillin-Binding Protein2a of Methicillin-Resistant Staphylococcus aureus Strain SO-1977 Isolated from Sudan(Evolutionary Bioinformatics, 2019) Mohamed, Sofia B; Adlan, Talal A; Khalafalla, Nagla A; Abdalla, Nusiba; Ali, Zainab SA; KA, Abdella Munir; Hassan, Mohamed M; Elnour, Mohammed-Ahmed BWhole genome sequencing of methicillin-resistant Staphylococcus aureus (MRSA) strain isolated from Sudan has led to a great deal of information, which allows the identification and characterization of some pivotal proteins. The objective of this study was to investigate the penicillin-binding proteins, PBP and PBP2a, of SO-1977 strain to have insights about their physicochemical properties and to assess and describe the interaction of some phytochemicals against them in silico. PBP and PBP2a from MRSA’s Sudan strain were found to be of great resemblance with some other strains. G246E single-nucleotide polymorphism was reported and identified in the allosteric binding site positioned in the non-penicillin-binding domain. The docked compounds demonstrated good binding energies and hydrogen bond interactions with residue Ser404 which plays crucial roles in β-lactam activity. This finding would contribute significantly to designing effective β-lactam drugs, to combat and treat β-lactam–resistant bacteria in the future.