Evaluation of Breast Cancer Metastasis to The Skeletal System by Using Bone Scintigraphy

Abstract

The aim of this study was to evaluate the breast cancer metastasis to specific preference parts of skeletal system using bones scintigraphy with consideration to metastatic from both breasts. The sample consists of 430 patients who refereed for bone scintigraphy at radiation and isotopes center in Khartoum during 2010-2013, after a confirmation of breast cancer based on histology, more variables as gender, age, involved quadrant and breast, anatomical sites of metastasis from both breast have been collected and analyzed. The analysis reveals that the left breast was highly involved by cancer 64% relative to right one. Breast cancer starts on age group of 20-30 years old and taking the plateau at 40-50 years old then decreases following aging. The right and left breasts cancer commonly gives metastases to lumbar vertebrae (26.7%, 22%), then dorsal vertebrae (14%, 19%), the pelvic bone (10%, 12.7%), the ribs (5%, 11.3%), the cervical vertebrae (8.7%, 10.7%), the skull (7.3%, ) and the femur bone with percentage of (6.7%, 10%) respectively and the right breast cancer gives higher metastatic percent to skeletal system segments 58.1% (250) than the left breast cancer41.9% (180), the predominant type of histopathology was Invasive ductal carcinoma (IDC) that representing 38% then the Adenoid

carcinoma 27% and invasive lobular carcinoma 17%. The common involved quadrant by cancer was the upper outer quad- rant UOQ 44%, inner upper quadrant 17%., lower outer quadrant LOQ, lower inner quadrant LIQ and the nipple showed

the following percentages 17%, 15%, 13%, and 11% respectively.