Salih, Hanaa IbrahimElsheikh, Mohammed AbdelgaderIdris, Alkhair Abd Almahmoud2025-10-252022https://dspace.nu.edu.sd/handle/nusu/198Background: Cyclin D1 plays a vital role in cancer cell cycle progression and it is overexpressed in manyhumancancers,includingcolorectalcancer. ThisstudyaimedtodetectcyclinD1incolorectal cancer patients and to correlate cyclin D1 expression with different pathological changes in the colorectum. Methods: Tissue microarray paraffin blocks with 48 colorectal cancer samples were retrieved from the archives of Elrahma Medical Center. Cyclin D1 was analyzed. Results: Cyclin D1 did not correlate with pathological alterations or with a particular tumor grade. Conclusion: The results indicate that cyclin D1 does not correlate with pathological alterations in colorectal cancerenCyclin D1Colorectal Cancercyclin-dependent kinasetumor gradeimmunohisto chemistry techniquetumor prognosisArticle