Measurement of Lipid Profiles in Patients with Acute Myocardial Infarction in Different Anti-Coagulants

Abstract

Background: Myocardial infraction is the death of heart muscle from the sudden blockage of coronary arterial vessel by a blood clot. Objectives: The aim of this study was to measure plasma/serum lipid concentrations in

patients with Acute Myocardial Infraction (AMI) within one week of onset of symptoms of AMI in different anti- coagulates. Methodology: This study was case-control study, match age and sex, carried out in Alshab Teaching

Hospital at Khartoum State in period from March to August 2007. Blood samples were collected in all subject study (patients and controls) and estimated the lipids in serum and plasma by colorimetric methods. Results: The (mean ±SD) serum/plasma cholesterol in patients were (162.43±33.78, 161.33±44.37, 161.10±46.94) and also in control subject were (161.43±42.08, 162.80±38.29, 167.70±4.43) respectively. The (mean ±SD) of serum/plasma triacylglycerol in patients and control were respectively (105.30±52.53, 11.70±49.61, 113.70±55.80) in controls were (112.70±57.17, 110.83±54.17, 105.93±42.25). The (mean ±SD) in serum/plasma high density lipoprotein in patients were (41.93±15.95, 38.10±13.65, 36.83±13.31) in control were (112.70±20.95, 110.83±19.63, 105.93±17.09). The (mean ±SD) in patients of low obesity lipoproteins were (99.73±43.27, 100.57±51.58, 102.63±51.25) and also control were (85.10±38.167, 92.93±22, 102.93±47.95) comparison between WHO recommended anti-coagulant (EDTD, Lithium heparin) LDL levels showed a significant difference (P=0.039) in plasma for lithium heparin as anti-coagulant, but HDL showed statistical difference (P=0.0) in both serum and plasma with EDTA. Conclusion: From this study it could be concluded that it might be better to use serum in the measurement of lipid profile than use anti-coagulant (EDTA and lithium heparin).