Evaluation of Serum Uric Acid and C- Reactive Proteins in Sudanese with Hypertension in Khartoum State

Abstract

Abstract—Uric acid is commonly associated with hypertension; recent experimental and clinical studies suggest that uric acid could have a contributory role in the pathogenesis of elevated blood pressure. Individuals at risk for developing hypertension and cardiovascular disease, frequently have evidence for a systemic

inflammatory response, often marked by elevations of C- reactive protein (CRP) in their blood. Elevated levels of

CRP have emerged as one of the most important predictors of myocardial infarction, stroke, and vascular death, with prognostic value exceeding that of LDL cholesterol. Aim: To evaluate, serum uric acid and CRP levels in Sudanese hypertensive patients in Khartoum state. Material and methods: 100 subjects in the age group of 25- 60 years, divided into two groups of hypertensive and control healthy normotensive group. (54) Patients suffering from hypertension and (46) ages matched non hypertension subjects, who were volunteered to be included in the study. Blood samples were collected in plain container for estimation of Serum C-RP and uric acid levels, Serum CRP levels were detected (qualitatively) using latex agglutination method (Spinreact Kit; 2016). Uric acid was estimated by quantitative commercial kit method (on Autoanalyzer Mindray. BS200). Venous blood sample was drawn from all subjects, allowed to clot at room temperature for 1–3 hours and serum was separated by centrifugation for 15 min at 3000 r. p. m. Data were analyzed using statistical package for the social sciences (SPSS). Result: The patients of hypertension under study comprised of 51.9% males and 48.1% females while the control comprised of 52.2% males and 47.8% females, the age range between 25 years to 60 years. Uric acid levels were high in 66.7 % of patients and normal in 33.3 % of patients. However uric acid levels observed within normal range in all normotensive subjects (control). CRP in 63 % of patients was positive while 37 % were negative and all control was negative. There was strong significant positive correlation between uric acid and CRP with P- value 0.000. Conclusion: Serum uric acid levels were found higher in hypertensive patients than in healthy individuals. Serum CRP in hypertensive patients shows higher percentage than in healthy individuals.