ESTIMATION OF SERUM TRIIODOTHYRONINE (T3), THYROXIN (T4) AND THYROID STIMULATING HORMONE (TSH) IN CIGARETTE SMOKERS IN KHARTOUM STATE

Abstract

Background: Cigarette smoking has a number of effects on the thyroid gland including the development of Graves’ disease and thyroid multi-nodularity. However, the effect of smoking on thyroid function is more uncertain. This study aimed to estimate the levels of thyroid hormones in cigarette smokers Materials and Methods: This study was designed as acase-controlon80 participants,40 of who were smokers as case and 40 were non-smokers as control in Khartoum State (2016- 2017). Serum T3, T4 and TSH were measured by ELISA (Enzyme-Linked Immunosorbent Assay) (URIT-660 micro-plate reader made in China serial number 66001674 E) Results:Were expressed as: (Mean +SD) and sig-2 tailed Pearson: Serum T3 level in smokers was (.063 ng/ml+ 0.18); in non-smokers was (1.48ng/ml + 0.26) and a p value of 0.0000001; T4 level in smokers was (2.75μg/dl + 0.67); in non-smokers was (5.79μg/dl +0.60) and a p value of 0.000000, and TSH level in smokers was (0.62 μIU/ml + 0.38); in non-smokers was (0.38μIU/ml +0.08) and p value of 0.009. Conclusion: Serum T3 and T4 levels in Sudanese smokers was decreased when compared to the levels in non-smokers. WhereasTSH levels were similar