National University - Sudan (NUSU)
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Item Possible role of inflammasomes in the pathogenesis of periodontal diseases(Preprints, 2023) Hashim, Nada; Babiker, Rasha; Mohammed, Riham; Gismalla, Bakri; Rehman, Mohammed MustahsenDr. Jurg Tschopp created the word "inflammasome" in 2002. Inflammasome activation and its function in disease processes have been the subject of significant investigation over the last 15 years. Four important inflammasomes have been identified: NLRP1, NLRP3, NLRC4, and AIM2. When these inflammasomes are activated, they process and secrete inflammatory cytokines such as IL-1b and IL-18, as well as cause pyroptosis, an inflammatory form of cell death. In this review, we will look at how these inflammasomes have been connected to Periodontitis pathogenesis.Item Highlighting the Effect of Pro‑inflammatory Mediators in the Pathogenesis of Periodontal Diseases and Alzheimer’s Disease(Journal of Pharmacy and Bioallied Sciences, 2024) Hashim, Nada; Babiker, Rasha; Mohammed, Riham; Chaitanya, Nallan CSK; Rahman, Muhammed M.; Gismalla, BakriAlzheimer’s disease (AD) is a neurological condition that is much more common as people get older. It may start out early or late. Increased levels of pro‑inflammatory cytokines and microglial activation, both of which contribute to the central nervous system’s inflammatory state, are characteristics of AD. As opposed to this, periodontitis is a widespread oral infection brought on by Gram‑negative anaerobic bacteria. By releasing pro‑inflammatory cytokines into the systemic circulation, periodontitis can be classified as a “low‑grade systemic disease.” Periodontitis and AD are linked by inflammation, which is recognized to play a crucial part in both the disease processes. The current review sought to highlight the effects of pro‑inflammatory cytokines, which are released during periodontal and Alzheimer’s diseases in the pathophysiology of both conditions. It also addresses the puzzling relationship between AD and periodontitis, highlighting the etiology and potential ramifications.