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Start date: 2023Subject: search.filters.subject.alcohol intake

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    Detection of Cytological changes in buccal mucosa among Sudanese alcohol drinkers
    (JOURNAL OF BIOLOGICAL RESEARCH AND REVIEWS, 2024) Idris, Alkhair Abd Almahmoud; Mustafa, Mohammed Abuzied; Yousif, Hassan Moutasim; Hammad, Mohammed Aldai; Elsheikh, Mohammed Abdelgader
    Aim: Chronic alcohol consumption led to a number of cytological changes in the mouth including inflammatory cell, fungal infection, bacterial infection, viral infection, dyskaryo sis, and malignant changes. The study aimed to detect the cytological changes of buccal mucosa causing by alcohol consumptions. Methods: This laboratory-based study included a total number of 50 patients of alco hol consumption and 25 non-alcohol drinkers which were collected from healthy people. Samples collected were two buccal smears from the buccal mucosa of alcohol consumers, using a tongue depressor, before that washed mouth to avoid contamination of bacteria. Results: The percentage of inflammatory change in age groups 10–20 was 3%, 21–30 was 6%, 31–40 was 20%, 41–50 was 26%, and the last group 51–60 was 45%. The cytological findings showed in the study population, the normal result there was 28% but the inflammatory changes show is very significant was 60% while the infected changes and dyskaryosis were not significant was 6% for each. Conclusions: This descriptive laboratory study confirmed the effectiveness of alcohol on buccal mucosa which led to abnormality of cytological findings like inflammatory changes, infected changes, dyskaryosis, and malignant changes due to excessive alcohol intake.
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    Impact of Lifestyle Modifications on Cancer Mortality: A Systematic Review and Meta-Analysis
    (Medicina, 2025) Rabbani , Syed Arman; Patni, Mohamed Anas; El-Tanani, Mohamed; Rangraze, Imran Rashid; Wali, Adil Farooq; Babiker, Rasha; Satyam, Shakta Mani; El-Tanani, Yahia; Almetwally, Abdelrahman Adel MohamedShehata
    Abstract: Background and Objectives: Cancer survival poses significant challenges in oncol ogy, with lifestyle modifications increasingly recognized as crucial in modifying patient outcomes post-diagnosis. This meta-analysis aims to systematically evaluate the impact of various lifestyle interventions on cancer survival across different types of cancer. Methods: Acomprehensive literature search of electronic databases including PubMed, Scopus and Cochrane was performed to identify relevant studies up to 30 November 2024. Relevant studies were chosen and data were extracted and analyzed using SPSS Version 29.0 soft ware. Results: Our systematic review included data from 98 studies involving a total of 1,461,834 cancer patients to evaluate the impact of lifestyle factors on cancer survival. Out of these, 64 studies were included in the meta-analysis. Our meta-analysis demonstrates that adherence to specific dietary patterns significantly improves cancer-specific outcomes. The Healthy Eating Index (HEI) diet was associated with a reduction in cancer-specific mortality (pooled log HR: −0.22; 95% CI: [−0.32, −0.12]; p < 0.001). Similar benefits were observed with the Mediterranean diet (aMED), which also reduced cancer mortality and recurrence (pooled log HR: −0.24; 95% CI: [−0.40, −0.07]; p < 0.001), and the Dietary Approaches to Stop Hypertension (DASH) diet (pooled log HR: −0.22; 95% CI: [−0.33, −0.12]; p < 0.001). Additionally, general dietary improvements were beneficial for breast cancer-specific mortality across 17 cohort studies (pooled log HR: −0.15; 95% CI: [−0.25, −0.06]; p < 0.001). Engaging in any form of physical activity post-diagnosis was associated with significant improvements in cancer-specific mortality or recurrence (pooled log HR: −0.31; 95% CI: [−0.38, −0.25]; p < 0.001). Participants who ceased smoking after diagnosis exhibited more favorable cancer outcomes (pooled log HR: −0.33; 95% CI: [−0.42, −0.24]; p <0.001), with smoking cessation notably reducing cancer-specific mortality among lung cancer survivors (pooled log HR: −0.34; 95% CI: [−0.48, −0.20]; p < 0.001). Additionally, reducing alcohol intake post-diagnosis significantly improved cancer outcomes (pooled log HR: −0.26; 95% CI: [−0.33, −0.19]; p < 0.001). Alcohol moderation in gastrointestinal tract cancer survivors specifically decreased both cancer-specific mortality and recurrence (pooled log HR: −0.22; 95% CI: [−0.29, −0.15]; p < 0.001). Conclusions: Lifestyle modifica tions after cancer diagnosis significantly improve cancer-specific outcomes. Specific dietary patterns, increased physical activity, smoking cessation, and reduced alcohol intake are all associated with lower cancer-specific mortality. Integrating these lifestyle changes into oncology care may enhance patient survival and quality of life.

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