National University - Sudan (NUSU)

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    Causes of end stage renal failure among haemodialysis patients in Khartoum State/Sudan
    (2015) Banaga,Amin S. I; Mohammed,Elaf B; Siddig,Rania M; Salama,Diana E; Elbashir,Sara B; Khojali,Mohamed O; Babiker,Rasha A; Elmusharaf,Khalifa; Homeida,Mamoun M
    Background: End stage renal failure (ESRF) has become a major health problem in Sub Saharan Africa (SSA). There were limited data about causes of ESRF in the Sudan. Methods: This is a cross sectional hospital based descriptive study. The subjects of the study are ESRF adults’ patients on regular haemodialysis treatment in 15 haemdoialysis centres in Khartoum State—Sudan. Clinical and epidemio- logical data were obtained from 1583 patients. The medical files of each patient were reviewed to identify the cause of ESRF. Concerning the causes of ESRF, diabetes was diagnosed based on the past medical history and result of the glucose tolerance test, hypertension was diagnosed based on past history of hypertension based on blood pressure of more than 140/90 mmHg, glomerulonephritis was diagnosed based on results of previous kidney biopsies and on clinical grounds, polycystic kidney disease and obstructive uropathy were diagnosed based on abdominal ultrasound and other imaging modalities, sickle cell anaemia was diagnosed based on the result of haemoglobin electrophoresis, systemic lupus erythematosus was diagnosed based on the clinical criteria in addition to lab results of auto antibod- ies, and analgesic nephropathy was diagnosed based on past medical history of chronic analgesic drugs usage with no other identifiable risk factors. We included all ESRF patients on regular haemodialysis treatment. We excluded ESRF patients less than 18 years old. Results: The results showed that the mean age of ESRF Patients was 49 ± 15.8 (years) and 63.4 % were male and 76.3 % were unemployed. The mean duration of haemodialysis is 4.38 ± 4.24 (years). The most common cause of ESRF in our patients was hypertension (34.6 %) followed by chronic glomerulonephritis (17.6 %), diabetes mellitus (12.8 %), obstructive uropathy (9.6 %), autosomal dominant poly cystic kidney disease (ADPKD) (4.7 %), chronic pyelonephritis (4.6 %), analgesic nephropathy (3.5 %). However in (10.7 %) no cause was found. In patient aged less than 40 years old the leading cause of ESRF was glomerulonephritis (29.3 %) followed by hypertension (25 %). In patient aged between 40 to 60 years old the leading cause of ESRF was hypertension (38.5 %) followed by diabetes mellitus (14 %). In patient aged older than 60 years the leading cause of ESRF was hypertension (38.4 %) followed by diabetes mellitus (23.3 %). Conclusions: ESRF in Sudan affects the economically productive age group; unemployment rate among ESRF patients is high. The study showed that hypertension is a leading cause of ESRF in Sudan followed by chronic glomer- ulonephritis. Hypertension and diabetes mellitus are the leading causes of ESRF among patients over 40 years old.
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    Why Did Sudanese End Stage Renal Failure Patients Refuse Renal Transplantation?
    (Open Journal of Nephrology, 2015) Banaga,Amin S; Mohammed,Elaf B; Siddig,Rania M; Salama,Diana E; Elbashir,Sara B; Khojali,Mohamed O; Babiker,Rasha A; Elmusharaf,Khalifa; Homeida,Mamoun M
    Renal transplantation remains the most effective treatment of End Stage Renal Failure (ESRF). In this cross sectional study we explore the reasons behind refusal of renal transplantation among adults’ Sudanese haemodialysis patients. The subjects of the study are ESRF adults’ patients on regular haemodialysis treatment in 15 haemdoialysis centres in Khartoum/Sudan. All patients who are on regular haemodialysis were interviewed by questionnaire to explore the reasons of refusal of renal transplantation. A total of 1583 ESRF adults’ patients on regular haemodialysis have been participated in the study, 381 (24.1%) patients refused kidney transplantation. The mean age of patients refusing kidney transplantation was (58.5 + 15.1 years); 77.4% of them were ≥50 years old, 59.2% were males and 88.1% were unemployed, patients older than 50 years old and unemployed are tend to refuse renal transplantation (P < 0.001). The main reason of refusal was that the patients refuse to accept kidney from living donors (34.8%). 17.6% of patients de- cline kidney transplantation because of financial reason, 18.1% of patients refused to do trans- plantation because of fear of transplant surgery, 15.7% of patients believe that kidney transplan- tation is against their religious values, 11.9% of patients refused transplantation because they don’t have enough knowledge on renal transplantation, only 0.5% of patients refuse transplanta- tion because of side effect of immunosuppressive drugs. In conclusion, in this study we found that elderly and unemployed ESRF patients tend to refuse renal transplantation, the most important reason behind refusal of renal transplantation is refusal of accepting kidney donation from living related donors. This reflects the need for development of cadaveric donors program in the Sudan. ESRF patients need education and counseling on renal transplantation.
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    Case report of a novel homozygous splice site mutation in PLA2G6 gene causing infantile neuroaxonal dystrophy in a Sudanese family
    (BMC Medical Genetics, 2018) Elsayed,Liena E. O; Mohammed,Inaam N; Hamed,Ahlam A. A; Elseed,Maha A; Salih,Mustafa A. M; Yahia,Ashraf; Siddig,Rayan A; Amin,Mutaz; Koko,Mahmoud; Elbashir,Mustafa I; Ibrahim,Muntaser E; Brice,Alexis; Ahmed,Ammar E; Stevanin,Giovanni
    Background: Infantile neuroaxonal dystrophy (INAD) is a rare hereditary neurological disorder caused by mutations in PLA2G6. The disease commonly affects children below 3 years of age and presents with delay in motor skills, optic atrophy and progressive spastic tetraparesis. Studies of INAD in Africa are extremely rare, and genetic studies from Sub Saharan Africa are almost non-existent. Case presentation: Two Sudanese siblings presented, at ages 18 and 24 months, with regression in both motor milestones and speech development and hyper-reflexia. Brain MRI showed bilateral and symmetrical T2/FLAIR hyperintense signal changes in periventricular areas and basal ganglia and mild cerebellar atrophy. Whole exome sequencing with confirmatory Sanger sequencing were performed for the two patients and healthy family members. A novel variant (NM_003560.2 c.1427 + 2 T > C) acting on a splice donor site and predicted to lead to skipping of exon 10 was found in PLA2G6. It was found in a homozygous state in the two patients and homozygous reference or heterozygous in five healthy family members. Conclusion: This variant has one very strong (loss of function mutation) and three supporting evidences for its pathogenicity (segregation with the disease, multiple computational evidence and specific patients’ phenotype). Therefore this variant can be currently annotated as “pathogenic”. This is the first study to report mutations in PLA2G6 gene in patients from Sudan.
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    Bioinformatics in Sudan: Status and challenges case study: The National University-Sudan
    (PLOS COMPUTATIONAL BIOLOGY, 2021) Mohamed, Sofia B; Kambal, Sumaya; Ibrahim, Sabah A.E.; Abdalwhab, Esra; Munir, Abdalla; Ibrahim, Arwa; Ali, Qurashi Mohamed
    The ever increasing applications of bioinformatics in providing effective interpretation of large and complex biological data require expertise in the use of sophisticated computa tional tools and advanced statistical tests, skills that are mostly lacking in the Sudanese research community. This can be attributed to paucity in the development and promotion of bioinformatics, lack of senior bioinformaticians, and the general status quo of inadequate research funding in Sudan. In this paper, we describe the challenges that have encountered the development of bioinformatics as a discipline in Sudan. Additionally, we highlight on spe cific actions that may help develop and promote its education and training. The paper takes the National University Biomedical Research Institute (NUBRI) as an example of an institute that has tackled many of these challenges and strives to drive powerful efforts in the devel opment of bioinformatics in the country.
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    Proteomics and Docking Study Targeting Penicillin Binding Protein and Penicillin-Binding Protein2a of Methicillin-Resistant Staphylococcus aureus Strain SO-1977 Isolated from Sudan
    (Evolutionary Bioinformatics, 2019) Mohamed, Sofia B; Adlan, Talal A; Khalafalla, Nagla A; Abdalla, Nusiba; Ali, Zainab SA; KA, Abdella Munir; Hassan, Mohamed M; Elnour, Mohammed-Ahmed B
    Whole genome sequencing of methicillin-resistant Staphylococcus aureus (MRSA) strain isolated from Sudan has led to a great deal of information, which allows the identification and characterization of some pivotal proteins. The objective of this study was to investigate the penicillin-binding proteins, PBP and PBP2a, of SO-1977 strain to have insights about their physicochemical properties and to assess and describe the interaction of some phytochemicals against them in silico. PBP and PBP2a from MRSA’s Sudan strain were found to be of great resemblance with some other strains. G246E single-nucleotide polymorphism was reported and identified in the allosteric binding site positioned in the non-penicillin-binding domain. The docked compounds demonstrated good binding energies and hydrogen bond interactions with residue Ser404 which plays crucial roles in β-lactam activity. This finding would contribute significantly to designing effective β-lactam drugs, to combat and treat β-lactam–resistant bacteria in the future.
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    The Humanitarian Crisis in Sudan: The Distorted Educational System
    (Napata Scientific Journal,, 2024) Saeed, Ali Awadallah; Kheir, Eman; Gibreel, Omer A.; Khalifa, Samah Elnour; Suliman, Maha Yahia; Almekkawi, Sawsan M.
    Introduction: On 15 April 2023, Battles initially broke out in the capital city, Khartoum, after the Rapid Support Forces (RSF) militia, which used to be under the command of the Sudanese Armed Forces (SAF), rebelled. During such a disaster, Sudanese people are expected to reconsider their life priorities, with education coming down after safety and food supply. This, in turn, will result negatively in children's learning outcomes with probable deterioration and or reduction in educational achievement. A report released by the Ministry of Higher Education and Scientific Research on 28 August 2023 stated that the vandalism affected all 104 higher education and scientific research institutions in Khartoum and several other states. Methodology: This commentary relies on reports from the Ministry of Higher Education and Scientific Research, along with recent journal articles discussing the consequences of ongoing conflicts. Personal observations as staff in universities contribute to the insights, and data from the students and colleges illuminate the struggles faced by them. Results: The war resulted in the widespread destruction of educational infrastructure, leaving more than 600,000 higher education students uncertain about their academic future. The universities started searching for solutions to overcome the catastrophe and find ways to support their students and staff. Conclusions: The conflict in Sudan disproportionately impacts education, causing disruptions in whole educational process in Sudan. Urgent international intervention is needed to cease the conflict and ensure the safety of higher education and scientific research institutions facilities, and support will be needed for the students, higher education staff and researchers.
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    Detection of Cytological changes in buccal mucosa among Sudanese alcohol drinkers
    (JOURNAL OF BIOLOGICAL RESEARCH AND REVIEWS, 2024) Idris, Alkhair Abd Almahmoud; Mustafa, Mohammed Abuzied; Yousif, Hassan Moutasim; Hammad, Mohammed Aldai; Elsheikh, Mohammed Abdelgader
    Aim: Chronic alcohol consumption led to a number of cytological changes in the mouth including inflammatory cell, fungal infection, bacterial infection, viral infection, dyskaryo sis, and malignant changes. The study aimed to detect the cytological changes of buccal mucosa causing by alcohol consumptions. Methods: This laboratory-based study included a total number of 50 patients of alco hol consumption and 25 non-alcohol drinkers which were collected from healthy people. Samples collected were two buccal smears from the buccal mucosa of alcohol consumers, using a tongue depressor, before that washed mouth to avoid contamination of bacteria. Results: The percentage of inflammatory change in age groups 10–20 was 3%, 21–30 was 6%, 31–40 was 20%, 41–50 was 26%, and the last group 51–60 was 45%. The cytological findings showed in the study population, the normal result there was 28% but the inflammatory changes show is very significant was 60% while the infected changes and dyskaryosis were not significant was 6% for each. Conclusions: This descriptive laboratory study confirmed the effectiveness of alcohol on buccal mucosa which led to abnormality of cytological findings like inflammatory changes, infected changes, dyskaryosis, and malignant changes due to excessive alcohol intake.
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    Exploring the quality of life of end-stage kidney disease patients in Khartoum State, Sudan: a multicenter cross-sectional study
    (BMC Nephrology, 2025) Hajomer, Hiba Ali Elzaki; Elkhidir, Osama Ahmed; Elawad, Sara; Ahmed, Ahmed Balla M.; Elawad, Shaima Omer Mohamed; Elbadawi, Mohamed H.; Elhassan, Wael Atif Fadl; Mohamed, Rafa Awad Gasimelseed; Ali, Kamil Merghani; Mahmoud, Tahani Amin; Kheir, Sarra Mohamed
    Background Given the rising incidence of end-stage kidney disease (ESKD) in Sudan, assessing health-related quality of life (HRQOL) is critical for evaluating patient outcomes. This study evaluated HRQOL and associated factors in end stage kidney disease patients in Khartoum State renal centers in Sudan. Methods This cross-sectional study administered the Kidney Disease Quality of Life Short Form (KDQOL-SF™) to 150 ESKD patients on maintenance dialysis for ≥ one month across 13 renal centers in Khartoum State. Data were analyzed using SPSS Statistics. Independent t-tests, ANOVA, Pearson correlation, and multiple regression analyses were conducted to assess associations. The p-value was set at 0.05 for statistical significance. Results The Physical (40.17 ± 9.01) and Mental (47.10 ± 9.86) Component scores significantly affected HRQOL in ESKD patients. The lowest scores were observed for burden of kidney disease (31.25 ± 38) and work status (0.00 ± 50). The SF-12 Physical Component was associated with employment status (p < 0.001) and dialysis accompaniment (p = 0.011). Diabetes comorbidity affected the Mental Component (p = 0.017). Hospitalization frequency showed significant negative correlations with the SF-12 Mental Component (r = -0.249), burden of kidney disease (r = -0.330), effects of kidney disease (r = -0.303), and Kidney Disease Component Summary (r = -0.247). In the multiple regression model for the SF-12 Physical Component, age group was the only significant factor (p = 0.023). Conclusion Both physical and mental health domains were significantly impaired in the studied ESKD population. The lowest scores were observed for disease burden and work status. Enhancing healthcare access, addressing comorbidities, and reducing financial strain may improve outcomes. Further longitudinal and case-control studies are warranted to clarify determinants of HRQOL.
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    Genomic analysis of methicillin-resistant Staphylococcus aureus strain SO-1977 from Sudan
    (BMC Microbiology, 2019) Ali,Mohamed S; Isa,Nurulfiza M; Abedelrhman,Faisal M; Alyas,Tahani B; Mohammed,Sara E; Ahmed,Abdallah E; Ahmed,Zainab S. A; Lau,Nyok-Sean; Garbi,Mohamed I; Amirul,Abdullah Al-Ashraf; Seed,Almeen O; Omer,Rihab A; Mohamed,Sofia B
    Background: Methicillin-resistant Staphylococcus aureus (MRSA) is known as a leading cause of morbidity and mortality. Investigation of the MRSA’s virulence and resistance mechanisms is a continuing concern toward controlling such burdens through using high throughput whole Genome Sequencing (WGS) and molecular diagnostic assays. The objective of the present study is to perform whole-genome sequencing of MRSA isolated from Sudan using Illumina Next Generation Sequencing (NGS) platform. Results: The genome of MRSA strain SO-1977 consists of 2,827,644 bp with 32.8% G + C, 59 RNAs and 2629 predicted coding sequences (CDSs). The genome has 26 systems, one of which is the major class in the disease virulence and defence. A total of 83 genes were annotated to virulence disease and defence category some of these genes coding as functional proteins. Based on genome analysis, it is speculated that the SO-1977 strain has resistant genes to Teicoplanin, Fluoroquinolones, Quinolone, Cephamycins, Tetracycline, Acriflavin and Carbapenems. The results revealed that the SO-1977, strain isolated from Sudan has a wide range of antibiotic resistance compared to related strains. Conclusion: The study reports for the first time the whole genome sequence of Sudan MRSA isolates. The release of the genome sequence of the strain SO-1977 will avail MRSA in public databases for further investigations on the evolution of resistant mechanism and dissemination of the -resistant genes of MRSA.
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    The Impact of War in Sudan on Renal Medical Services
    (National Journal of Community Medicine, 2025) Banaga, Amin SI

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